The Western clawed frog Xenopus tropicalis is a diploid model system for both frog genetics and developmental biology, complementary to the paleotetraploid X. laevis. Title: The Xenopus Tropicalis Genome Project VOLUME: 4 ISSUE: 8 Author(s):Paul M. Richardson and Jarrod Chapman Affiliation:US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598,USA. These include orthologs of 79% of identified human disease genes (4). husbandry, cell biology, imaging, genetics, transgenesis, genomics). X. tropicalis genome assembly 3.0 is the third of a series of preliminary assembly releases that are planned as part of the ongoing X. tropicalis genome The existence of both male and female … Recently Xenopus tropicalis has attracted increased attention as a model for developmental biology because it has a small diploid genome, unlike the African clawed frog (Xenopus laevis) and other species in this genus. While Xenopus laevis is the most commonly used species for developmental biology studies, genetic studies, especially forward genetic studies, can be complicated by their pseudotetraploid genome. The 2020 Xenopus Community White Paper is now available! Recently, the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated (CRISPR/Cas) system for genome modification has provided an additional tool for Xenopus researchers to achieve simple and efficient …
The genome assembly release v4.1 was annotated using the JGI annotation pipeline. In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis … As in most amphibians, sex chromosomes of the model species Xenopus tropicalis are homomorphic, complicating identification of the heterogametic sex. These resources include cDNA libraries, expressed sequence tags, full‐length cDNA sequences, genomic libraries, pilot projects to mutagenize and phenotype X. tropicalis , and sequencing the X. tropicalis genome. Title: The Xenopus Tropicalis Genome Project VOLUME: 4 ISSUE: 8 Author(s):Paul M. Richardson and Jarrod Chapman Affiliation:US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598,USA. Xenopus laevis, also known as the African clawed frog or platanna, is an important model organism that is used in the study of vertebrate cell and developmental biology. The Xenopus tropicalis genome is composed of more than 1.7 billion chemical bases spread out on 10 chromosomes. Xenopus tropicalis provides a simpler model for genetic studies, having a diploid genome. For the emerging amphibian genetic model Xenopus tropicalis targeted gene disruption is dependent on zinc-finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs), which require either complex design and selection or laborious construction.
Genome Project Notes. Genome Project Notes. A Xenopus tropicalis genome project advisory board was set up to insure an accurate and timely exchange of information between the JGI and the research community. Thus, easy and efficient genome editing tools are still highly desirable for this species. Xenopus tropicalis v10 genome - available to BLAST - view on JBrowse . Keywords:est, genome, Sequencing, xenopus Abstract: The Human Genome Project has resulted in the elucidation of the genomic sequence of a number of model organisms as … Amphibian Research Center) through collaboration between the Xenopus Community in Japan (XCIJ) and National Bio-Resource … While X. tropicalis is diploid, with two copies of each gene on 10 pairs of chromosomes, the X. laevis genome has undergone duplication and could have four copies of every gene on 18 pairs of chromosomes. Using genetic approaches, we have proved the existence of three types of sex chromosomes (Y, W, and Z), defining three kinds of males (YZ, YW, and ZZ) and two kinds of females (ZW and WW).
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